A deficiency of intrinsic factor should alert the nurse to assess for which condition?

A deficiency of intrinsic factor is crucial because intrinsic factor is a glycoprotein produced by the parietal cells in the stomach that is essential for the absorption of vitamin B12 in the intestines. Without sufficient intrinsic factor, the body cannot properly absorb vitamin B12, leading to a condition known as pernicious anemia.

Pernicious anemia is characterized by the deficiency of vitamin B12, which is vital for red blood cell production and proper neurological function. Symptoms may include fatigue, weakness, pale skin, and neurological issues like numbness or tingling in the hands and feet. Thus, when a nurse identifies a deficiency of intrinsic factor, it is vital to assess for signs and symptoms associated with pernicious anemia, as this condition directly results from the impaired absorption of vitamin B12 caused by the lack of intrinsic factor.